Copper(I)-catalyzed addition of trifluoromethylated benzyl radicals derived from aryltrifluoroethyl bromides to terminal olefins |
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Authors: | Takashi Okano |
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Institution: | Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan |
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Abstract: | Relatively unreactive aryltrifluoroethyl bromides were reacted with 1-octene in the presence of CuCl and 2,2′-bipyridyl at high temperatures. Trifluoromethylated benzyl radical was generated, and a diastereomer mixture of radical adducts was obtained with a (60-70):(40-30) diastereomer ratio. Ph3SnH reduction of the adducts gave the corresponding hydrocarbons with an isolated trifluoromethyl group. The reactions with styrene or aromatic and aliphatic silyl enol ethers led to the formation of trifluorodiphenylbutene and β-trifluoromethylated ketones, respectively. |
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Keywords: | Trifluoromethyl compound Radical addition Atom-transfer reaction Cu(I) catalysts Tin hydride reduction |
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