Synthesis and biological activity of N-(2-hydroxyethyl)cytisine derivatives |
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| Authors: | D. V. Shishkin A. R. Shaimuratova A. N. Lobov N. Z. Baibulatova L. V. Spirikhin M. S. Yunusov N. S. Makara N. Zh. Baschenko V. A. Dokichev |
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| Affiliation: | (1) Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, 450054 Ufa, prosp. Oktyabrya, 71 |
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| Abstract: | Derivatives of N-(2-hydroxyethyl)cytisine, N-(2-hydroxypropyl)-, N-(2-hydroxy-2-(1-adamantyl)ethyl)-, and N-(2-hydroxy-2-phenylethyl)cytisine, were synthesized by reduction of N-(2-oxopropyl)-, N-(2-oxo-2-(1-adamantyl)ethyl)-and N-(2-oxo-2-phenylethyl)cytisine with metal hydrides. The antiarrhythmic and analgesic activities of the prepared compounds were investigated. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 157–162, March–April, 2007. |
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| Keywords: | cytisine N-(2-hydroxyethyl)cytisine derivatives reduction metal hydrides antiarrhythmic and analgesic activity |
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