Synthesis and Structural Conformation Studies of a Potent Unsymmetrical 1,4-Dihydropyridine |
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Authors: | S. Naveen Sridhar M. Anandalwar J. Shashidhara Prasad Dinesh Manvar Arun Mishra Anamik Shah |
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Affiliation: | (1) Department of Studies in Physics, University of Mysore, Mysore, 570 006, India;(2) Department of Chemistry, Saurashtra University, Rajkot, 360 005, India |
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Abstract: | Abstract 2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies. The molecule crystallizes in the monoclinic crystal class in the spacegroup P21/c with cell parameters a = 10.5960(6) ?, b = 10.2450(7) ?, c = 19.5790(11) ?, β = 107.448(3)° and Z = 4. The 1,4-dihydropyridine ring in the structure adopts a flattened boat conformation. Graphical Abstract 2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies. The molecule crystallizes in the monoclinic crystal class in the spacegroup P21/c with cell parameters a = 10.5960(6) ?, b = 10.2450(7) ?, c = 19.5790(11) ?, β = 107.448(3)° and Z = 4. The 1,4-dihydropyridine ring in the structure adopts a flattened boat conformation. |
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Keywords: | 1,4-Dihydropyridine Flat boat Hydrogen bond |
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