Synthesis and Structural Conformation Studies of a Potent Unsymmetrical 1,4-Dihydropyridine |
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| Authors: | S Naveen Sridhar M Anandalwar J Shashidhara Prasad Dinesh Manvar Arun Mishra Anamik Shah |
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| Institution: | (1) Department of Studies in Physics, University of Mysore, Mysore, 570 006, India;(2) Department of Chemistry, Saurashtra University, Rajkot, 360 005, India |
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| Abstract: | Abstract 2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was
characterized spectroscopically and confirmed by X-ray diffraction studies. The molecule crystallizes in the monoclinic crystal
class in the spacegroup P21/c with cell parameters a = 10.5960(6) ?, b = 10.2450(7) ?, c = 19.5790(11) ?, β = 107.448(3)° and Z = 4. The 1,4-dihydropyridine ring in the structure adopts a flattened boat conformation.
Graphical Abstract 2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was
characterized spectroscopically and confirmed by X-ray diffraction studies. The molecule crystallizes in the monoclinic crystal
class in the spacegroup P21/c with cell parameters a = 10.5960(6) ?, b = 10.2450(7) ?, c = 19.5790(11) ?, β = 107.448(3)° and Z = 4. The 1,4-dihydropyridine ring in the structure adopts a flattened boat conformation.
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| Keywords: | 1 4-Dihydropyridine Flat boat Hydrogen bond |
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