Reactions of cisplatin hydrolytes, cis-[Pt(15NH3)2(H2O) 2]2+, with N-acetyl-L-cysteine |
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Authors: | Sutopo Hadi and Trevor G Appleton |
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Institution: | (1) Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Road, 214122 Wuxi, China;(2) Fermentation and Ecological Engineering Laboratory (FEEL), School of Biotechnology, Jiangnan University, 1800 Lihu Road, 214122 Wuxi, Jiangsu Province, China; |
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Abstract: | The reaction of cis-Pt(15NH3)2(H2O) 2] 2+ (3) with N-acetylcysteine H3accys] was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. A
mono-dentate sulfur-boundplatinum(II) product cis-Pt(15NH3)2(H2O)(H2accys-S)]+ (7) and six-membered che-late ring complex cis-Pt(15NH3)2 (Haccys-S,O)] (8) were formed in solution. The dinuclear sulfur-bridged complex 9, giving a broad peak in 15N NMR, was also observed, but only present in very tiny amounts. The mass spectrometry (ES-MS) was undertaken from this re
action, and the product detected was only the dinuclear sulfur bridged platinum species and species related to it by ammine
loss. |
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Keywords: | |
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