Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage |
| |
| Authors: | Rajkumar Tulsawani Lorena S Kelly Nigar Fatma Bhavanaben Chhunchha Eri Kubo Anil Kumar and Dhirendra P Singh |
| |
| Institution: | 1.Department of Ophthalmology and Visual Sciences,University of Nebraska Medical Center,Omaha,USA;2.Department of Neurosurgery,University of Nebraska Medical Center,Omaha,USA;3.Department of Ophthalmology,University of Fukui,Fukui,Japan;4.Department of Pharmacology and Toxicology,University of Missouri- Kansas City,Kansas City,USA |
| |
| Abstract: | Background The ability to respond to changes in the extra-intracellular environment is prerequisite for cell survival. Cellular responses
to the environment include elevating defense systems, such as the antioxidant defense system. Hypoxia-evoked reactive oxygen
species (ROS)-driven oxidative stress is an underlying mechanism of retinal ganglion cell (RGC) death that leads to blinding
disorders. The protein peroxiredoxin 6 (PRDX6) plays a pleiotropic role in negatively regulating death signaling in response
to stressors, and thereby stabilizes cellular homeostasis. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
