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A variant of the bruylants reaction. Synthesis of 4-heteroaryl-4-anilinopiperidines. |
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| Authors: | Linas V Kudzma H Kenneth Spencer Sherry A Severnak |
| Institution: | Anaquest BOC Group Technical Center 100 Mountain Avenue, Murray Hill, NJ 07974 U.S.A. |
| Abstract: | Imines can be generated in situ from  -aminonitriles and efficiently trapped by a variety of lithiated heterocycles. This variation of the Bruylants reaction has proven to be a general method for the synthesis of -heteroaryl secondary amines. |
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