Comprehensive ultra-high pressure capillary liquid chromatography/ion mobility spectrometry |
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Authors: | D C Collins Y Xiang M L Lee |
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Institution: | (1) Department of Criminal Justice, Weber State University, Ogden, 84408-1206, Utah;(2) Department of Chemistry and Biochemistry, Brigham Young University, Provo, 84602-5700, Utah |
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Abstract: | Summary An ultra-high pressure liquid chromatograph was interfaced to a moderately high-resolution nanoelectrospray ionization ion
mobility spectrometer operating at ambient temperature and pressure to achieve fast multidimensional separations. The potential
of using ion mobility spectrometry as the second dimension in a comprehensive arrangement with liquid chromatography to offer
improved qualitative information for compounds under specific operating conditions, is discussed. Separation and detection
of selected benzodiazepines and triazine herbicides are demonstrated. Composite peak capacities of 39 and 33 for benzodiazepine
and triazine herbicide mixtures, respectively, were achieved in less than 75 s using a 16.5 cm×50 μm internal diameter fused
silica capillary liquid chromatographic column packed with 1.5 μm diameter ODS-bonded silica particles. |
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Keywords: | Column liquid chromatography Ion mobility spectrometry Nanoelectrospray ionization Comprehensive multidimensional separations |
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