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Concise synthesis of dl-febrifugine |
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| Authors: | Takeuchi Yasuo Oshige Miyo Azuma Kumiko Abe Hitoshi Harayama Takashi |
| Institution: | Faculty of Pharmaceutical Sciences, Okayama University, Japan. take@pharm.okayama-u.ac.jp |
| Abstract: | Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an omega-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7). |
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