| BF_3·OEt_2 Promoted Solvent-free Synthesis of Benzimidazole Derivatives |
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| 作者姓名： | Rahul R.NAGAWADE Devanand B.SHINDE |
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| 作者单位： | Division of Medicinal Chemistry-New Drug Discovery Wockhardt Research Centre，Aurangabad-431210 (M.S.)，India Department of Chemical Technology，Dr.Babasaheb Ambedkar Marathwada University，Aurangabad-431004 (M.S.)，India，Department of Chemical Technology，Dr.Babasaheb Ambedkar Marathwada University，Aurangabad-431004 (M.S.)，India |
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| 摘 要： | Differently substituted benzimidazoles have been synthesized in very good yields in solvent-free conditions from o-phenylenediamine and aldehydes in the presence of BF3·OEt2 as a catalyst. The method is applicable to aromatic, unsaturated and aliphatic aldehydes and to substituted o-phenylenediamines without significant differences.
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| 关 键 词： | BF3·OEt2 aldehydes benzimidazoles solvent-free reactions drugs. |
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