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Enantioselective Total Synthesis of the Lignan (+)‐Linoxepin |
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| Authors: | Prof Lutz F Tietze Dr Jérôme Clerc Simon Biller Dr Svenia‐C Duefert Dr Matthias Bischoff |
| Institution: | 1. Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universit?t G?ttingen, Tammannstrasse 2, 37077 G?ttingen (Germany);2. Present address: Max‐Planck‐Institute für Psychiatry, Kraepelinstrasse 2, 80804 München (Germany) |
| Abstract: | An enantioselective total synthesis of the natural (+)‐linoxepin ( 1 ) was accomplished in eleven steps from bromovanin ( 24 ). Key steps are a domino carbopalladation/ Mizoroki–Heck reaction with the formation of a pentacyclic system, an asymmetric hydroboration as well as an oxidative lactonization. |
| Keywords: | asymmetric hydroboration carbopalladation lignans natural products total synthesis |