Copper‐Catalyzed Reductive Cross‐Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides |
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| Authors: | Jing‐Hui Liu Chu‐Ting Yang Xiao‐Yu Lu Zhen‐Qi Zhang Ling Xu Mian Cui Xi Lu Bin Xiao Prof. Dr. Yao Fu Prof. Dr. Lei Liu |
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| Affiliation: | 1. Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P. R. China);2. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou (P. R. China);3. Department of Chemistry, Tsinghua University, Beijing 100084 (P. R. China) |
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| Abstract: | A copper‐catalyzed reductive cross‐coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost‐effective construction of aryl–alkyl and alkyl–alkyl C?C bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo‐ or heterocycles, such as 2,3‐dihydrobenzofuran and benzochromene derivatives. |
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| Keywords: | catalysis C C bond formation copper cross‐coupling cyclization |
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