A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols |
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| Authors: | Dr. José A. Fernández‐Salas Simone Manzini Steven P. Nolan |
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| Affiliation: | 1. EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST (UK);2. Chemistry Department, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia) |
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| Abstract: | A synthetic protocol making use of a well‐defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec‐alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantioenriched acetates in a one‐pot reaction, probing the versatility of complex 2 . |
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| Keywords: | dynamic kinetic resolution enzyme catalysis metal catalysis racemization ruthenium |
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