Cyclobutene Formation in PtCl2‐Catalyzed Cycloisomerizations of Heteroatom‐Tethered 1,6‐Enynes |
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Authors: | Zhenjie Ni Dr. Laurent Giordano Dr. Alphonse Tenaglia |
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Affiliation: | Aix‐Marseille Université, Centrale Marseille, CNRS, ISm2, UMR 7313, 13397 Marseille (France) |
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Abstract: | Aza(oxa)bicyclo[3.2.0]heptenes are accessed through the PtCl2‐catalyzed cycloisomerizations of heteroatom‐tethered 1,6‐enynes featuring a terminal alkyne and amide as the solvent. It is shown that the weak coordinating properties of the solvent and alkyl substituent(s) at the propargylic carbon atom favor the formation of cyclobutenes instead of other possible cycloisomerization products such as 1,3‐diene derivatives or cyclopropane‐fused heterocycles. |
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Keywords: | cyclobutenes cycloisomerization enynes platinum small ring systems solvent effects |
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