Asymmetric Hetero‐Diels–Alder Reaction of Danishefsky’s Diene with α‐Ketoesters and Isatins Catalyzed by a Chiral N,N′‐Dioxide/Magnesium(II) Complex |
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| Authors: | Jianfeng Zheng Dr Lili Lin Kai Fu Yulong Zhang Prof?Dr Xiaohua Liu Prof?Dr Xiaoming Feng |
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| Institution: | Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86)?28‐8541‐8249 |
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| Abstract: | A highly enantioselective hetero‐Diels–Alder reaction of Danishefsky’s diene with α‐ketoesters and isatins has been realized by using a chiral N,N′‐dioxide/MgII complex. In the presence of only 0.1–0.5 mol % catalyst, a series of substrates were transformed into the corresponding tetrasubstituted 2,3‐dihydropyran‐4‐ones in up to 99 % yield and more than 99 % ee in two hours. |
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| Keywords: | asymmetric catalysis cycloaddition diene ligands magnesium spiro compounds |
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