Copper‐Catalyzed Mild Nitration of Protected Anilines |
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| Authors: | Elier Hernando Dr Rafael R Castillo Dr Nuria Rodríguez Dr Ramón Gómez?Arrayás Prof?Dr Juan C Carretero |
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| Institution: | Departamento de Química Orgánica, Universidad Autónoma de Madrid (UAM), Facultad de Ciencias, Cantoblanco 28049 Madrid (Spain) |
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| Abstract: | A practical copper‐catalyzed direct nitration of protected anilines, by using one equivalent of nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N‐protecting group and arene substitution), and high functional‐group tolerance. Dinitration with two equivalents of nitric acid is also feasible. |
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| Keywords: | anilines benzimidazoles copper nitration nitric acid |
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