Drug Encapsulation and Release by Mesoporous Silica Nanoparticles: The Effect of Surface Functional Groups |
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| Authors: | Si Yu Tan Chung Yen Ang Peizhou Li Qi Ming Yap Prof Dr Yanli Zhao |
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| Institution: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21?Nanyang Link, Singapore 637371 (Singapore) http://www.ntu.edu.sg/home/zhaoyanli/;2. School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798 (Singapore) |
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| Abstract: | Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli‐responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide‐appended functional ligands on the surface of MSNPs on drug‐loading capacity and glutathione‐triggered drug‐release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theβ‐cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug‐delivery experiments on a melanoma cell line (B16‐F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery. |
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| Keywords: | drug delivery ligand effects mesoporous silica nanoparticles release kinetics surface functionalization |
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