Palladium‐Catalyzed Carbonylation of 2‐Bromoanilines with 2‐Formylbenzoic Acid and 2‐Halobenzaldehydes: Efficient Synthesis of Functionalized Isoindolinones |
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| Authors: | Dr Kishore Natte Jianbin Chen Haoquan Li Dr Helfried Neumann Prof?Dr Matthias Beller Prof?Dr Xiao‐Feng Wu |
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| Institution: | Leibniz‐Institut für Katalyse an der Universit?t Rostock e.V, Albert‐Einstein‐Str. 29a, 18059 Rostock (Germany) |
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| Abstract: | A concise and highly versatile method for the synthesis of functionalized isoindolinones is reported. Various 2‐bromoanilines undergo palladium‐catalyzed carbonylation with 2‐formylbenzoic acid under a convenient and mild procedure to give good to excellent yields of the corresponding isoindolinones. Additionally, 2‐halobenzaldehydes can be applied as substrates in palladium‐catalyzed double‐carbonylation to provide identical compounds in moderate to good yields. |
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| Keywords: | carbonylation cascade reactions heterocycles isoindolinones palladium |
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