Selective Stabilization of Abasic Site‐Containing DNA by Insertion of Sterically Demanding Biaryl Ligands |
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| Authors: | Dr Katja Benner Dr Anna Bergen Prof?Dr Heiko Ihmels Phil Marvin Pithan |
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| Institution: | Department Chemie ‐ Biologie, Universit?t Siegen, Adolf‐Reichwein‐Str. 2, 57068 Siegen (Germany) |
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| Abstract: | Biaryl derivatives that consist of one DNA‐intercalating unit and a sterically demanding component exhibit a specific behavior towards abasic site‐containing DNA (AP‐DNA) as determined by thermal DNA denaturation experiments, spectrometric titrations and CD spectroscopic analysis. Specifically, these ligands strongly stabilize AP‐DNA towards dissociation, whereas they do not or only marginally affect the melting temperature of regular duplex DNA. |
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| Keywords: | abasic DNA DNA damage DNA ligands DNA recognition nitrogen heterocycles |
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