Allosteric Binding of Capsaicin by a Bis(β‐cyclodextrin)‐2,2′‐bipyridine Receptor |
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| Authors: | Christopher Kremer Prof?Dr Arne Lützen |
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| Institution: | Kekulé‐Institut für Organische Chemie und Biochemie, Rheinische Friedrich‐Wilhelms‐Universit?t Bonn, Gerhard‐Domagk‐Strasse 1, 53121 Bonn (Germany), Fax: (+49)?228‐73‐9608 |
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| Abstract: | A new β‐cyclodextrin‐based receptor that showed allosteric binding behavior towards capsaicin in aqueous solution was prepared. By NMR titration and nonlinear regression, we obtained binding constants, which increased more than fivefold when an effector (Zn2+) was bound to a central 2,2′‐bipyridine that acts as the allosteric center. |
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| Keywords: | allosteric regulations bipyridines capsaicin cyclodextrins host– guest systems |
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