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Enantiopure Isoindolinones through Viedma Ripening |
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| Authors: | René R. E. Steendam Maxime C. T. Brouwer Evelien M. E. Huijs Michaël W. Kulka Dr. Hugo Meekes Dr. Willem J. P. van Enckevort Dr. Jan Raap Prof. Dr. Floris P. J. T. Rutjes Prof. Dr. Elias Vlieg |
| Affiliation: | 1. Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands);2. Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden (The Netherlands) |
| Abstract: | Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst. |
| Keywords: | asymmetric amplification chiral resolution chirality grinding heterocycles |