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[18F]CuCF3: A [18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides |
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| Authors: | Dr. Pavel Ivashkin Dr. Gérald Lemonnier Jonathan Cousin Prof. Dr. Vincent Grégoire Dr. Daniel Labar Prof. Dr. Philippe Jubault Prof. Dr. Xavier Pannecoucke |
| Affiliation: | 1. Normandie Univ., COBRA, UMR 6014 et FR 3038, Univ. Rouen;2. INSA Rouen;3. CNRS, 1 rue Tesnière, 76821 Mont Saint‐Aignan Cedex (France);4. Centre for Molecular Imaging, Radiotherapy and Oncology (MIRO), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Av. Hippocrate, 54, 1200‐Brussels (Belgium) |
| Abstract: | Positron emission tomography has emerged as the leading method for medical imaging with fluorine‐18 as the most widely used radioactive isotope. Here we report a semi‐automated method for the preparation of valuable [18F]trifluoromethylcopper, as well as its use for the radiosynthesis of [18F]trifluoromethylarenes and heteroarenes. Mild conditions of [18F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [18F]trifluoromethylarenes and heteroarenes. |
| Keywords: | arylboronic acid copper fluorine radiochemistry trifluoromethylation |