A Direct CH/ArH Coupling Approach to Oxindoles,Thio‐oxindoles, 3,4‐Dihydro‐1 H‐quinolin‐2‐ones,and 1,2,3,4‐Tetrahydroquinolines |
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| Authors: | Dr Timothy E Hurst Ryan M Gorman Pauline Drouhin Dr Alexis Perry Prof Richard J K Taylor |
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| Institution: | 1. Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK), Fax: (+44)?1904324523;2. Physics and Medical Imaging, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Physics Building, Stocker Road, Exeter, EX4 4QL (UK) |
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| Abstract: | A copper(II)‐catalysed approach to oxindoles, thio‐oxindoles, 3,4‐dihydro‐1H‐quinolin‐2‐ones, and 1,2,3,4‐tetrahydroquinolines via formal C?H, Ar?H coupling is described. In a new variant, copper(II) 2‐ethylhexanoate has been identified as an inexpensive and efficient catalyst for this transformation, which utilises atmospheric oxygen as the re‐oxidant. |
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| Keywords: | dihydroquinolinones catalysis copper oxindoles tetrahydroquinolines |
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