Palladium‐Catalyzed α‐Arylation of Arylketones at Low Catalyst Loadings |
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| Authors: | Enrico Marelli Dr Martin Corpet Sian R Davies Prof?Dr Steven P Nolan |
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| Institution: | 1. EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST (UK);2. Chemistry Department, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia) |
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| Abstract: | A general catalytic protocol for the α‐arylation of aryl ketones has been developed. It involves the use of a preformed, bench‐stable Pd–N‐heterocyclic carbene pre‐catalyst bearing IHept as an ancillary ligand, and allows the coupling of various functionalized coupling partners at very low catalyst loading. Careful choice of the solvent/base system was crucial to obtain optimum catalyst performance. The pre‐catalyst was also successfully tested in the synthesis of an industrially relevant compound. |
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| Keywords: | catalysts ketone arylation monodentate ligands NHC palladium |
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