Ruthenium(II)‐Catalyzed CH Activation with Isocyanates: A Versatile Route to Phthalimides |
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Authors: | Dr. Suman De Sarkar Prof. Dr. Lutz Ackermann |
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Affiliation: | Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universit?t G?ttingen, Tammannstrasse 2, 37077 G?ttingen (Germany), Fax: (+49)?551‐39‐6777 |
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Abstract: | A cationic ruthenium(II)‐complex was utilized in the efficient synthesis of phthalimide derivatives by C?H activation with synthetically useful amides. The reaction proceeded through a mechanistically unique insertion of a cycloruthenated species into a C?Het multiple bond of isocyanate. The novel method also proved applicable for the synthesis of heteroaromatic unsymmetric diamides as well as a potent COX‐2 enzyme inhibitor. |
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Keywords: | amides C H activation imidation isocyanate ruthenium |
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