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Methyl Substitution Regulates the Enantioselectivity of Supramolecular Complex Binding to Human Telomeric G‐Quadruplex DNA |
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| Authors: | Bailu Xu Dr Chuanqi Zhao Dr Yong Chen Prof Hisae Tateishi‐Karimata Prof Jinsong Ren Prof Naoki Sugimoto Prof Xiaogang Qu |
| Institution: | 1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022 (P. R. China);2. FIBER, Konan University, Kobe (Japan) |
| Abstract: | Chiral supramolecular compounds with substituents at different positions show different binding properties with human telomeric G‐quadruplex DNA. These different positions of methyl substitution in chiral supramolecular compounds can modulate their enantioselectivity and structural preference when binding with human telomeric G‐quadruplex DNA. |
| Keywords: | chirality G‐quadruplex methyl substitution supramolecular chemistry telomerase inhibition |