Selective Catalytic Behavior of a Phosphine‐Tagged Metal‐Organic Framework Organocatalyst |
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| Authors: | Xiaoying Xu Stephan M. Rummelt Flavien L. Morel Dr. Marco Ranocchiari Prof. Dr. Jeroen A. van Bokhoven |
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| Affiliation: | 1. Department of Chemistry and Applied Biosciences, Laboratory of Chemical and Bioengineering, ETH Zurich, 8093 Zürich (Switzerland);2. Department of Synchrothron Radiation, Laboratory for Catalysis and Sustainable Chemistry, Paul Scherrer Institute, 5232 Villigen PSI (Switzerland) |
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| Abstract: | Steric hindrance by a metal–organic framework (MOF) is shown to influence the outcome of a catalytic reaction by controlling the orientation of its intermediates. This is demonstrated using an organocatalyst, phosphine MOF LSK‐3, which is evaluated with the aid of molecular modeling and NMR spectroscopy techniques. This report is the first application of phosphine MOFs in organocatalysis and explores the potential of a framework steric hindrance to impose selectivity on a catalytic reaction. These findings expand the opportunities for control and design of the active site in the pocket of heterogeneous catalysts. |
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| Keywords: | heterogeneous catalysis metal– organic frameworks organocatalysis phosphines selectivity |
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