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High‐Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO2 Heterogeneous Catalyst |
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| Authors: | Dr Kirill V Kovtunov Danila A Barskiy Aaron M Coffey Dr Milton L Truong Oleg G Salnikov Alexander K Khudorozhkov Elizaveta A Inozemtseva Dr Igor P Prosvirin Prof Valery I Bukhtiyarov Dr Kevin W Waddell Dr Eduard Y Chekmenev Prof Igor V Koptyug |
| Institution: | 1. Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia) and Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090 (Russia);2. Institute of Imaging Science, Department of Radiology, Department of Biomedical Engineering, Department of Physics and Astronomy, and Department of Biochemistry, Nashville, Tennessee, 37232‐2310 (USA);3. Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090 (Russia) |
| Abstract: | Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years. 3D 1H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm3) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time. |
| Keywords: | heterogeneous catalysis hyperpolarized gas magnetic resonance imaging parahydrogen supported catalysts |