High Relaxivity Mn2+‐Based MRI Contrast Agents |
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Authors: | Dr. Martín Regueiro‐Figueroa Dr. Gabriele A. Rolla Dr. David Esteban‐Gómez Dr. Andrés de Blas Dr. Teresa Rodríguez‐Blas Prof. Mauro Botta Dr. Carlos Platas‐Iglesias |
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Affiliation: | 1. Departamento de Química Fundamental, Universidade da Coru?a, Campus da Zapateira, Rúa da Fraga 10, 15008 A Coru?a (Spain);2. Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “A. Avogadro”, Viale T. Michel 11, 15121, Alessandria (Italy) |
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Abstract: | Stable Mn2+ mono‐ and binuclear complexes containing pentadentate 6,6′‐((methylazanediyl)bis(methylene))dipicolinic acid coordinating units give remarkably high relaxivities due to the presence of two inner‐sphere water molecules. The mononuclear derivative binds human serum albumin (HSA) with an association constant of 3372 M ?1, which results in the replacement of the coordinated water molecules by donor atoms of protein residues. The dinuclear analogue also binds HSA while leaving one of the Mn2+ centres exposed to the solvent with two coordinated water molecules. Thus, this complex shows remarkably high relaxivities upon protein binding (39.0 mM ?1 s?1 per Mn, at 20 MHz and 37 °C). |
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Keywords: | contrast agents coordination compounds human serum albumin manganese NMR imaging |
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