Metal‐Free CN‐ and NN‐Bond Formation: Synthesis of 1,2,3‐Triazoles from Ketones,N‐Tosylhydrazines,and Amines in One Pot |
| |
| Authors: | Zhengkai Chen Qiangqiang Yan Zhanxiang Liu Prof Dr Yuhong Zhang |
| |
| Institution: | 1. ZJU‐NHU United R&D Center, Department of Chemistry, Zhejiang University, Hangzhou 310027 (P. R. China);2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (P. R. China) |
| |
| Abstract: | A novel synthetic approach toward 1,4‐disubstituted 1,2,3‐triazoles by C?N‐ and N?N‐bond formation has been established under transition‐metal‐free conditions. Complete control of the regioselectivity was successfully achieved. Commercially available anilines, ketones, and N‐tosylhydrazine were treated with molecular iodine in one pot to allow the regioselective generation of 1,4‐disubstituted 1,2,3‐triazoles in high yields without the use of azides. |
| |
| Keywords: | anilines ketones metal‐free reactions synthetic methods 1 2 3‐triazoles |
|
|
