Cyclocondensation of 3-Amino-1,2,4-triazoles with Esters of Substituted Cinnamic Acids and Aromatic Unsaturated Ketones |
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Authors: | V. V. Lipson S. M. Desenko V. D. Orlov O. V. Shishkin M. G. Shirobokova V. N. Chernenko L. I. Zinov'eva |
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Affiliation: | (1) Ukrainian Scientific-Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov, 61002;(2) V. N. Karazin Kharkov National University, Kharkov, 61077, Ukraine;(3) Institute of Single Crystals, Kharkov, 61001, Ukraine |
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Abstract: | We have studied the reactions of 3-amino, 3,5-diamino-, and 3-amino-5-trifluoromethyl-1,2,4-triazole with esters of substituted cinnamic acids and aromatic unsaturated ketones; we have established the directionality of formation of the tetrahydrooxopyrimidine ring. We have carried out hydrolysis and hydrazinolysis of 7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5-one. We have conducted an X-ray diffraction study of isopropylidene hydrazide of 3-(5-amino-1,2,4-triazol-1-yl)-3-phenylpropionic acid. |
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Keywords: | 3-amino-1,2,4-triazoles arylidenemethyl ketones 7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5-one esters of cinnamic acids X-ray diffraction analysis |
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