化学生物学新前沿--化学蛋白质组学

随着包括人类在内的主要模式生物的基因组计划的完成,生命科学的研究重心转向蛋白质组的研究--在对应基因组的整体蛋白质水平上系统研究调控细胞生命活动的蛋白质.化学蛋白质组学是化学生物学在后基因组时代的最新发展:化学蛋白质组学利用化学小分子为工具和手段,以基于靶蛋白质功能的新战略探测体内蛋白质组,是新一代的功能蛋白质组学.本文综述了化学蛋白质组学的最新进展、有关技术及其在生物医学和药物研发等方面的应用,并对化学蛋白质组学的发展趋势和前景进行了讨论.

New Frontier in Chemical Biology: Chemical Proteomics

The knowledge of complete genome sequences of leading organisms is dramatically changing the landscape of life science. In order to further understand how expression proteins in entire genome work together in complex biological system, a genomics-based technique termed proteomics has been developed to globally study protein identities and functions in cellular proteome. Recently, chemical proteomics emerged as a new proteomic technique. Employing target-directed chemical molecules, chemical proteomics uses innovative strategies to probe protein function at the proteome level thus is established as a promising function-based proteomic approach. The development and prospect of chemical proteomics and its main applications, especially in the fields of biological research and drug discovery are reviewed.