IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study |
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Authors: | Chrystelle Brignone Caroline Grygar Manon Marcu Gaëlle Perrin Frédéric Triebel |
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Affiliation: | (1) Immutep S.A., Parc Club Orsay, 2 rue Jean Rostand, 91893 Orsay, France |
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Abstract: | Background LAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of monocyte-derived dendritic cells in vitro and is used as a potent Th1-like immune enhancer with many antigens in animal models. To extend this observation to human, a proof of concept study was conducted with a clinical-grade sLAG-3, termed IMP321, coinjected with alum-non-absorbed recombinant hepatitis B surface antigen. |
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