Capillary electrophoresis with wavelength-resolved laser-induced fluorescence detection |
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Authors: | Xin Zhang Jeffrey N. Stuart Jonathan V. Sweedler |
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Affiliation: | Department of Chemistry, University of Illinois, Urbana IL 61801, USA. |
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Abstract: | Capillary electrophoresis (CE) enables rapid separations with high separation efficiency and compatibility with small sample volumes. Laser-induced fluorescence detection can result in extremely low limits of detection in CE. Single-channel fluorescence detection, however, furnishes little qualitative information about a species being detected, except for its CE migration time. Use of multidimensional information often enables unambiguous identification of analytes. Combination of CE with information-rich wavelength-resolved fluorescence detection is analogous with ultraviolet-visible diode-array detection and furnishes both qualitative and quantitative chemical information about target species. This review discusses recent advances in wavelength-resolved laser-induced fluorescence detection coupled with CE, with an emphasis on instrument design. |
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