Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine |
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Authors: | K E Kongshaug S Pedersen-Bjergaard K E Rasmussen M Krogh |
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Institution: | (1) School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway |
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Abstract: | Summary Impurity profiling of ecstacy and amphetamine seizures was accomplished by solid-phase microextraction (SPME) combined with
capillary gas chromatography (GC). Samples were dissolved in 0.1 M aqueous acetate buffer (pH 5.0) as the only manual operation
and subsequently subjected to SPME-GC. Ecstacy tablets were analyzed by head-space SPME to avoid contamination of SPME fibers
with insoluble tablet components, while illicit amphetamine powders were exposed to immersed SPME. A SPME fiber of polydimethylsiloxane-divinylbenzene
was found to provide excellent extraction of both polar and non-polar impurities. For both illicit ecstacy and amphetamine,
complex impurity profiles were obtained by SPME providing a high information content. For ecstacy, profiles (relative peak
areas) were repeatable within 2.2 to 12.6% RSD (n=6) while similar data on amphetamine varied between 2.0 and 10.9% RSD (n=6).
No carry-over was observed although each fiber was used for 50 to 100 extractions. |
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Keywords: | Capillary gas chromatography Solid-phase microextraction Amphetamine Ecstacy |
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