Detection of perfluorocarbons in blood by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry. |
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| Authors: | J C Mathurin J de Ceaurriz M Audran M P Krafft |
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| Institution: | Laboratoire National de Dépistage du Dopage, Chatenay Malabry, France. jc.mathurin@wanadoo.fr |
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| Abstract: | A new method of detection of perfluorocarbon molecules (PFCs) in blood sample has been established. After an extraction and pre-concentration step performed by headspace solid-phase microextraction (HS-SPME), the PFCs are detected by gas chromatography-mass spectrometry (GC/MS) with an ion trap mass spectrometer in MS and MS/MS modes. The influence of different parameters on the SPME process is discussed. The limit of detection and the linearity of the procedure have been determined for two PFCs. |
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