| 血浆中洛伐他汀含量测定的色谱-质谱法 |
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| 引用本文： | 郑文晖,蔡葵花,吴耀良.血浆中洛伐他汀含量测定的色谱-质谱法[J].分析测试学报,2000,19(4):69-70. |
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| 作者姓名： | 郑文晖 蔡葵花 吴耀良 |
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| 作者单位： | 1. 中山医科大学,分子医学研究中心,广东,广州,510089
2. 中山医科大学,附属第一医院检验部,广东,广州,510089 |
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| 摘 要： | 用色谱－质谱法测定血浆中洛伐他汀，采用辛伐他汀作内标，以乙酸乙酯为萃取液，经真空抽干，定容进样。洛伐他汀质量浓度在０．３６～４８ｍｇ／Ｌ之间线性关系较好。该法灵敏度高，前处理简单快速，检出限达０．１ｍｇ／Ｌ，相对标准偏差小于８．９％，回收率大于９２％。
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| 关 键 词： | 洛伐他汀 色谱－质谱法 血浆 降血脂药 测定 |
| 文章编号： | ： |
Determination of Lovastatin in Human Plasma by GC-MS |
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| ZHENG Wen-hui,CAI Kui-hua,WU Yao-liang.Determination of Lovastatin in Human Plasma by GC-MS[J].Journal of Instrumental Analysis,2000,19(4):69-70. |
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| Authors: | ZHENG Wen-hui CAI Kui-hua WU Yao-liang |
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| Abstract: | A method for the determination of lovastatin in human plasma was established by GC-MS with ion monitoring mode. Simvastatin was used as an internal standard. Sample was extracted by ethyl ace_tate, and then the extractive was used to detect after vacuum drying and fixed volume. The standard curve is linear in the range from 0.36 to 48 mg/L for lovastatin with correlation coefficient of 0.995. The method is sensitive with detection limit of 0.1 mg/L. The relative standard deviation(RSD) for intra _ day detection was found to be less than 5.0%, while RSD for inter _ day detection to be less than 8.9%. The recoveries are more than 92%. |
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| Keywords: | Lovastatin GC-MS SIM Plasma |
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