A quantum chemical study on the free radical scavenging activity of tyrosol and hydroxytyrosol |
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Authors: | Email author" target="_blank">Annia?GalanoEmail author Email author" target="_blank">Juan?Raúl?Alvarez-IdaboyEmail author Misaela?Francisco-Márquez Manuel?E?Medina |
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Institution: | 1.Departamento de Química,Universidad Autónoma Metropolitana-Iztapalapa,Mexico D.F.,Mexico;2.Departamento de Física y Química Teórica, Facultad de Química,Universidad Nacional Autónoma de México,Mexico D.F.,Mexico;3.UPIICSA, Instituto Politécnico Nacional,Mexico D.F.,Mexico |
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Abstract: | The free radical scavenging activity of hydroxytyrosol (HTyr) and tyrosol (Tyr) has been studied in aqueous and lipid solutions,
using the density functional theory. Four mechanisms of reaction have been considered: single electron transfer (SET), sequential
electron proton transfer (SEPT), hydrogen transfer (HT), and radical adduct formation. It was found that while SET and SEPT
do not contribute to the overall reactivity of HTyr and Tyr toward ·OOH and ·OCH3 radicals, they can be important for their reactions with ·OH, ·OCCl3, and ·OOCCl3. The ·OOH-scavenging activity of HTyr and Tyr was found to take place exclusively by HT, and it is also predicted to be the main
mechanism for their reactions with ·OCH3. HT is proposed as the main mechanism for the scavenging activity of HTyr and Tyr when reacting with other ·OR and ·OOR radicals, provided that R is an alkyl or an alkenyl group. The major products of reaction are predicted to be the phenoxyl
radicals. In addition, Tyr was found to be less efficient than HTyr as free radical scavenger. Moreover, while HTyr is predicted
to be a good peroxyl scavenger, Tyr is predicted to be only moderately for that purpose. |
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