| EXPERIMENTAL STUDIES ON THE LATE EFFECTS OF FEMALE SEX HORMONES |
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| 作者姓名： | 高凤鸣 蒋涵英 于雁南 李新兰 王文惠 |
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| 作者单位： | Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC |
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| 基金项目： | This work was funded in part by the Bureau of Science and Education, Ministry of Public Health, PRC. |
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| 摘 要： | Inj. Hydroxyprogesterone Co. (EP) was injected i.m. into female Wistar rats, different strains of mice of both sex and Syrian golden hamsters with doses of 5--100 times the human contraceptive dose once or twice a month for 10--32 times. In some experiments EP was combined with whole-body 3 Gy gamma ray radiation once or twice. Results show that EP has obvious carcinogenicity and can enhance the gamma ray carcinogenicity, thereby increasing the tumor incidence or the ratio of malignant to benign turnouts. Carcinogenic mechanisms of EP have also been studied.
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EXPERIMENTAL STUDIES ON THE LATE EFFECTS OF FEMALE SEX HORMONES |
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| GAO FENG-MING JIANG HAN-YING YU YAN-NAN LI XIN-LAN AND WANG WEN-HUI.EXPERIMENTAL STUDIES ON THE LATE EFFECTS OF FEMALE SEX HORMONES[J].Science in China(Chemistry),1990(3). |
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| Authors: | GAO FENG-MING JIANG HAN-YING YU YAN-NAN LI XIN-LAN AND WANG WEN-HUI |
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| Abstract: | Inj. Hydroxyprogesterone Co. (EP) was injected i.m. into female Wistar rats, different strains of mice of both sex and Syrian golden hamsters with doses of 5--100 times the human contraceptive dose once or twice a month for 10--32 times. In some experiments EP was combined with whole-body 3 Gy gamma ray radiation once or twice. Results show that EP has obvious carcinogenicity and can enhance the gamma ray carcinogenicity, thereby increasing the tumor incidence or the ratio of malignant to benign turnouts. Carcinogenic mechanisms of EP have also been studied. |
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| Keywords: | estradiol valerate hydroxyprogesterone eaproate carcinogenesis neoplastic transformation gamma rays |
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