pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization |
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| Authors: | Zou Jiong Jafr Goran Themistou Efrosyni Yap Yoonsing Wintrob Zachary A P Alexandridis Paschalis Ceacareanu Alice C Cheng Chong |
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| Institution: | Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA. |
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| Abstract: | Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release. |
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