Rhodium‐Catalyzed Enantioselective Reductive Arylation: Convenient Access to 3,3‐Disubstituted Oxindoles |
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Abstract: | A rhodium‐Josiphos(L*) catalyzed enantioselective intramolecular hydroarylation reaction is described. The reductive cyclization of o ‐bromoaniline‐derived acrylamides provides convenient access to 3,3‐disubstituted oxindoles in good yields and with excellent enantioselectivity across a range of substrates. We propose that the key cyclization proceeds via a rhodium(III) intermediate. Overall, this method represents an unusual mode of reactivity for rhodium catalysis and is complementary to palladium(0)‐catalyzed α‐arylation methods. |
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Keywords: | Cyclisierungen Homogene Katalyse Oxindole Reduktive Arylierungen Rhodium |
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