Stereospecific 1,3‐Aminobromination of Donor–Acceptor Cyclopropanes |
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Abstract: | Sn(OTf)2‐catalyzed 1,3‐aminobromination of donor–acceptor cyclopropanes with various sulfonyl amides or electron‐poor anilines and N ‐bromosuccinimide is reported. These experimentally straightforward reactions occurred with complete regio‐ and stereospecificity (for anilines) to give γ‐aminated α‐brominated malonic diesters in good to excellent yields (up to 98 %). These compounds served as valuable substrates for subsequent reactions to provide substituted azetidines and γ‐lactams in high yields. |
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Keywords: | 1 3-Aminobromierungen Azetidine Donor-Akzeptor-Cyclopropane γ -Lactame Stereospezifitä t |
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