A Biosurfactant‐Inspired Heptapeptide with Improved Specificity to Kill MRSA |
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| Authors: | Yuan Liu Prof Dr Shuangyang Ding Dr Richard Dietrich Prof Dr Erwin Märtlbauer Dr Kui Zhu |
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| Institution: | 1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Yuanmingyuan West Road No.2, Beijing, 100193 China;2. Institute of Food Safety, Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, 85764 Oberschleißheim, Germany;3. Department of Biomedical Engineering, Duke University, Durham, NC, 27708 USA |
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| Abstract: | The emergence and rapid spread of methicillin‐resistant Staphylococcus aureus (MRSA) poses a serious threat to public health. New antibiotics and strategies are urgently needed to combat S. aureus associated infections. Bacaucin, a novel cyclic lipopeptide from Bacillus subtilis CAU21, is reported. Bacaucin shows broad antibacterial activity against Gram‐positive bacteria, but is also hemolytic and cytotoxic. However, bacaucin‐1, a bacaucin‐inspired ring‐opened heptapeptide, shows specific antibacterial activity against MRSA by a membrane‐disruptive mechanism without detectable toxicity to mammalian cells or induction of bacterial resistance. Bacaucin‐1 was efficient in preventing infections in both in vitro and in vivo models and is a valuable prototype antibiotic with high potential against S. aureus infections. |
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| Keywords: | Antibiotika Bakterien MRSA Peptide Wirkstoffentwicklung |
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