| Abstract: | By using mechanistic insight, a new ligand (EPhos) for the palladium‐catalyzed C−N cross‐coupling between primary amines and aryl halides has been developed. Employing an isopropoxy group at the C3‐position favors the C‐bound isomer of the ligand‐supported palladium(II) complexes and leads to significantly improved reactivity. The use of a catalyst system based on EPhos with NaOPh as a mild homogeneous base proved to be very effective in the formation of 4‐arylaminothiazoles and highly functionalized 2‐arylaminooxazoles. Previously, these were not readily accessible using palladium catalysis. |
