Visible‐Light‐Mediated Remote Aliphatic C−H Functionalizations through a 1,5‐Hydrogen Transfer Cascade |
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Abstract: | A redox‐neutral, light‐mediated functionalization of unactivated C(sp3)−H bonds via iminyl radicals is presented here. A 1,5‐H transfer followed by the functionalization of a C(sp2)−H bond takes place in aqueous media producing a variety of elaborated fused ketones. Mechanistic investigations have revealed 1,5‐H transfer as the reversible, rate‐determining step in this transformation. Divergent scaffolds are also accessible via C(sp3)−N bond formation upon a careful choice of the reaction additives. |
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Keywords: | 1,5-H-Transfer C-H-Funktionalisierung Dihydro-2H-pyrrol Photoredoxreaktionen Tetralone |
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