Interprotein Electron Transfer between FeS‐Protein Nanowires and Oxygen‐Tolerant NiFe Hydrogenase

Self‐assembled redox protein nanowires have been exploited as efficient electron shuttles for an oxygen‐tolerant hydrogenase. An intra/inter‐protein electron transfer chain has been achieved between the iron‐sulfur centers of rubredoxin and the FeS cluster of [NiFe] hydrogenases. [NiFe] Hydrogenases entrapped in the intricated matrix of metalloprotein nanowires achieve a stable, mediated bioelectrocatalytic oxidation of H₂ at low‐overpotential.