Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds |
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| Authors: | Haider Norbert Kabicher Tamara Käferböck Johann Plenk Angelika |
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| Affiliation: | Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Austria. norbert.haider@univie.ac.at |
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| Abstract: | A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay. |
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