Synthesis of cytochrome c oxidase models bearing a Tyr244 mimic |
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Authors: | Collman James P Decréau Richard A Zhang Chi |
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Affiliation: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. jpc@stanford.edu |
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Abstract: | A close structural analogue of the metal-free cytochrome c oxidase active site has been synthesized. This model has a proximal imidazole tail and three distal imidazole pickets attached to a porphyrin. One distal imidazole is cross-linked to a phenol, mimicking Tyr(244). The strategy behind the successful synthesis of this regioisomerically pure model involved discovering the best sequence to introduce the phenol-substituted imidazole and employing a fluorinated substituent. |
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