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Recognition and elimination of diversified pathogens in insect defense systems
Authors:Shoichiro Kurata
Institution:(1) Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan
Abstract:Summary The elimination of infectious non-self by the host defense systems of multicellular organisms requires a variety of recognition and effector molecules. The diversity is generated in somatic cells or encoded in the germ-line. In adaptive immunity in jawed vertebrates, the diversity of immunoglobulins and antigen receptors is generated by gene rearrangements in somatic cells. In innate immunity, various effector molecules and pattern recognition receptors, such as antimicrobial peptides and peptidoglycan recognition proteins, are encoded in the germ-line of multicellular organisms, including insects and jawed vertebrates. In the present review, we discuss how insect host defense systems recognize and eliminate a multitude of microbes via germ-line-encoded molecules, including recent findings that a Drosophila member of the immunoglobulin superfamily is extensively diversified by alternative splicing in somatic immune cells and participates in the elimination of bacteria.
Keywords:antimicrobial peptides  Down syndrome cell adhesion molecule  immunoglobulin-superfamily  pathogens  pattern recognition receptors  peptidoglycan recognition protein
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