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A short and efficient enantioselective route to a key intermediate for the total synthesis of forskolin |
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| Authors: | E. J. Corey Paul Da Silva Jardine |
| Affiliation: | Department of Chemistry, Harvard University, Cambridge, Massachusetts, 02138 U.S.A. |
| Abstract: | A simple route for the enantioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Diels-Alder reaction to tricyclic lactone 9. |
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